Guggulsterone-releasing microspheres direct the differentiation of human induced pluripotent stem cells into neural phenotypes.
Agbay A, De La Vega L, Nixon G, Willerth SM.A Biomed Mater. 2018 Jan 25. doi: 10.1088/1748-605X/aaaa77 View Article
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.A Nature. 2018 Jan 25;553(7689):515-520. View Abstract
The Aspergillus fumigatus Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice
Nesbitt JR, Steves EY, Schonhofer CR, Cait A, Manku SS, Yeung JHF, Bennet AJ, McNagny KM, Choy JC, Hughes MR, Moore MM. Front Microbiol. 2018 Jan 18;8:2706. View Article
IL-6 expression is correlated with increased T-cell proliferation and survival in the arterial wall in giant cell arteritis
Manku S, Wong W, Luo Z, Seidman MA, Alabdurubalnabi Z, Rey K, Enns W, Avina-Zubieta JA, Shojania K, Choy JC. Cardiovasc Pathol. 2018 Mar - Apr;33:55-61. doi: 10.1016/j.carpath.2018.01.004. Epub 2018 Jan 9. View Article
Dr. Stephanie Willerth featured as Woman of Innovation in CIM Magazine
We are so proud to announce that Dr. Willerth was identified as a Woman of Innovation in CIM Magazine! Read her story here!
BCREGMED UBC Research Excellence Cluster Grant Renewed for 2018!
We are very pleased to announce that BCREGMED was successful in ourA UBC Research Excellence Cluster Application!A Thank you to the GCRC Review Committee! Lots of great things to come! More info here.
Localized Tacrolimus Delivery Repairs the Damaged Central Nervous System
Willerth SM. EBioMedicine. 2017 Dec;26:4-5. View Article
Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell mediated TNFI signaling
Wang, W.,Fujii, H., et al., Zandstra, P.W. Science Translational Medicine.2017 Dec. 9:421 eaag3214 DOI: 10.1126/scitranslmed.aag3214 View Paper
A repurposed drug could open door to more stem cell transplants
A medication used to treat joint and skin conditions might also help people whose only hope of surviving cancer is receiving stem cells from a donor, according to research by a University of British Columbia scientist. Transplants of blood stem cells, which can differentiate into all types of blood cells, can be a cure for life-threatening blood cancers like leukemia or lymphoma. But the treatment is often not pursued, because typical donations a often from umbilical cord blood a are unlikely to take root in a patienta s bone marrow and grow into a self-sustaining, blood-forming system. Researchers at UBC and [...]
FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors
Yoon, C., et al., Zandstra, P.W. Stem Cell Reports. 2018 Jan. 10:1-14. View Paper