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Cell competition during reprogramming gives rise to dominant clones
Shakiba, N., Fahmy, A., Jayakumaran, G., McGibbon, S., David, L., Trcka, D., Elbaz, J., Puri, M.C., Nagy, A., van der Kooy, D., Goyal, S., Wrana, J.L., Zandstra, P.W. Cell competition during reprogramming gives rise to dominant clones. View abstract.
The optoelectronic microrobot: A versatile toolbox for micromanipulation
Zhang, S., Scott, E.Y., Singh, J., Chen, Y., Zhang, Y., Elsayed, M., Dean Chamberlain, M., Shakiba, N., Adams, K., Yu, S., Morshead, C.M., Zandstra, P.W., Wheeler, A.R. The optoelectronic microrobot: A versatile toolbox for micromanipulation. View Abstract.
Soluble Wood Smoke Extract Promotes Barrier Dysfunction in Alveolar Epithelial Cells through a MAPK Signaling Pathway
Zeglinski, M.R., Turner, C.T., Zeng, R., Schwartz, C., Santacruz, S., Pawluk, M.A., Zhao, H., Chan, A.W.H., Carlsten, C., Granville, D.J. Soluble Wood Smoke Extract Promotes Barrier Dysfunction in Alveolar Epithelial Cells through a MAPK Signaling Pathway. View abstract.
A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease
Gibbs, E., Silverman, J.M., Zhao, B., Peng, X., Wang, J., Wellington, C.L., Mackenzie, I.R., Plotkin, S.S., Kaplan, J.M., Cashman, N.R. A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease. View abstract.
A novel motif in the proximal C-terminus of Pannexin 1 regulates cell surface localization
Epp, A.L., Ebert, S.N., Sanchez-Arias, J.C., Wicki-Stordeur, L.E., Boyce, A.K.J., Swayne, L.A. A novel motif in the proximal C-terminus of Pannexin 1 regulates cell surface localization. View abstract.
Innate control of tissue-reparative human regulatory T cells
Lam, A.J., MacDonald, K.N., Pesenacker, A.M., Juvet, S.C., Morishita, K.A., Bressler, B., Pan, J.G., Sidhu, S.S., Rioux, J.D., Levings, M.K. Innate control of tissue-reparative human regulatory T cells. View abstract.
Cancer stemness, intratumoral heterogeneity, and immune response across cancers
Miranda, A., Hamilton, P.T., Zhang, A.W., Pattnaik, S., Becht, E., Mezheyeuski, A., Bruun, J., Micke, P., de Reynies, A., Nelson, B.H. Cancer stemness, intratumoral heterogeneity, and immune response across cancers. View abstract.
In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants
Shafaattalab, S., Li, A.Y., Lin, E., Stevens, C.M., Dewar, L.J., Lynn, F.C., Sanatani, S., Laksman, Z., Morin, R.D., van Petegem, F., Hove-Madsen, L., Peter Tieleman, D., Davis, J.P., Tibbits, G.F. In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants. View abstract.
Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease
Tam, A., Hughes, M., McNagny, K.M., Obeidat, M., Hackett, T.L., Leung, J.M., Shaipanich, T., Dorscheid, D.R., Singhera, G.K., Yang, C.W.T., Paré, P.D., Hogg, J.C., Nickle, D., Sin, D.D. Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease. View abstract.
Podocalyxin is required for maintaining blood–brain barrier function during acute inflammation
Cait, J., Hughes, M.R., Zeglinski, M.R., Chan, A.W., Osterhof, S., Wilder Scott, R., Hernaez, D.C., Cait, A., Wayne Vogl, A., Bernatchez, P., Michael Underhill, T., Granville, D.J., Murphy, T.H., Roskelley, C.D., McNagny, K.M. Podocalyxin is required for maintaining blood–brain barrier function during acute inflammation. View abstract.
Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation
Toselli, C.M., Wilkinson, B.M., Paterson, J., Kieffer, T.J. Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation. View Abstract.
Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues
Pereira, S., O’Dwyer, S.M., Webber, T.D., Baker, R.K., So, V., Ellis, C.E., Yoon, J.S., Mojibian, M., Glavas, M.M., Karunakaran, S., Clee, S.M., Covey, S.D., Kieffer, T.J. Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues. View abstract.
HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression
Patel, N., Wang, J., Shiozawa, K., Jones, K.B., Zhang, Y., Prokop, J.W., Davenport, G.G., Nihira, N.T., Hao, Z., Wong, D., Brandsmeier, L., Meadows, S.K., Sampaio, A.V., Werff, R.V., Endo, M., Capecchi, M.R., McNagny, K.M., Mak, T.W., Nielsen, T.O., Underhill, T.M., Myers, R.M., Kondo, T., Su, L. HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression. View abstract. View abstract.
In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm
Cui, J.Z., Lee, L., Sheng, X., Chu, F., Gibson, C.P., Aydinian, T., Walker, D.C., Sandor, G.G.S., Bernatchez, P., Tibbits, G.F., van Breemen, C., Esfandiarei, M. In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm. View Abstract.
What triggers acute exacerbations of COPD? Why not ask the patient!
Milne, S., Sin, D.D. What triggers acute exacerbations of COPD? Why not ask the patient! View abstract.
Granzyme K expressed by classically activated macrophages contributes to inflammation and impaired remodeling
Turner CT, Zeglinski MR, Richardson KC, Zhao H, Shen Y, Papp A, Bird PI, Granville DJ. Granzyme K expressed by classically activated macrophages contributes to inflammation and impaired remodeling. J. Invest. Dermatol. doi: 10.1016/j.jid.2018.09.031. [Epub ahead of print] View Abstract
Talin autoinhibition regulates cell-ECM adhesion dynamics and wound healing in vivo
Haage A, Goodwin K, Whitewood A, Camp D, Bogutz A, Turner CT, Granville DJ, Lefebvre L, Plotnikov S, Goult BT, Tanentzapf G. Talin autoinhibition regulates cell-ECM adhesion dynamics and wound healing in vivo. 2018 Cell Rep. 27;25(9):2401-2416. DOI: 10.1016/j.celrep.2018.10.098 View Abstract
Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors
Krentz NAJ, Lee MYY, Xu EE, Sproul SLJ, Maslova A, Sasaki S & Lynn FC. Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors. Stem Cell Reports 11:1551-1564, 2018. DOI: 10.1016/j.stemcr.2018.11.008 View Abstract
Transdifferentiating Astrocytes Into Neurons Using ASCL1 Functionalized With a Novel Intracellular Protein Delivery Technology
Robinson M, Fraser I, McKee E, Scheck K, Chang L, Willerth SM. Transdifferentiating Astrocytes Into Neurons Using ASCL1 Functionalized With a Novel Intracellular Protein Delivery Technology. Front Bioeng Biotechnol. 2018 Nov 21;6:173.DOI: 10.3389/fbioe.2018.00173. eCollection 2018. View Abstract
Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice
Neumann UH, Kwon MM, Baker RK, Kieffer TJ. Am J Physiol Endocrinol Metab. 2018 Oct 9. doi: 10.1152/ajpendo.00159.2018. [Epub ahead of print] View Abstract
Taking regulatory T-cell therapy one step further
Sicard A, Boardman DA, Levings MK. Curr Opin Organ Transplant. 2018 Oct;23(5):509-515. View Abstract
Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules
Lee C, Robinson M, Willerth SM. ACS Chem Neurosci. 2018 Aug 22. [Epub ahead of print] View Abstract
Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction
Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, Franzke CW, Overall CM, Granville DJ. Sci Rep. 2018 Jun 26;8(1):9690. View Article
Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing
Shen Y, Zeglinski MR, Turner CT, Raithatha SA, Wu Z, Russo V, Oram C, Hiroyasu S, Nabai L, Zhao H, Bozin T, Westendorf K, Kopko I, Huang R, Arns S, Tan J, Zeng H, Boey A, Liggins R, Jaquith J, Cameron DR, Papp A, Granville DJ.
Exp Mol Med. 2018 May 30;50(5):68. View Article
Disruption of the Gut Microbiota With Antibiotics Exacerbates Acute Vascular Rejection
Rey K, Manku S, Enns W, Van Rossum T, Bushell K, Morin RD, Brinkman FSL, Choy JC. Transplantation. 2018 Mar 10. doi: 10.1097/TP.0000000000002169. [Epub ahead of print] View Article