BCRegMed is committed to catalyzing interdisciplinary, interinstitutional, intersectoral collaborations for effective knowledge translation and more efficient scientific discovery. Together we can foster high-impact research to enable innovation and clinical translation that will ultimately lead to improved human health and well-being. If you hear of any research you want us to showcase, please contact us!
Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization?
Tedesco S, De Majo F, Kim J, Trenti A, Trevisi L, Fadini GP, Bolego C, Zandstra PW, Cignarella A, Vitiello L.
Front Pharmacol. 2018 Feb 22;9:71. View article
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential
Judson RN, Quarta M, Oudhoff MJ, Soliman H, Yi L, Chang CK, Loi G, Vander Werff R, Cait A, Hamer M, Blonigan J, Paine P, Doan LTN, Groppa E, He W, Su L, Zhang RH, Xu P, Eisner C, Low M, Barta I, Lewis CB, Zaph C, Karimi MM, Rando TA, Rossi FM. Cell Stem Cell. 2018. 22(2):177-190. View Article
Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.
Yachie-Kinoshita A, Onishi K, Ostblom J, Langley MA, Posfai E, Rossant J, Zandstra PW. Mol Syst Biol. 2018 Jan 29;14(1):e7952. View Article
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.A Nature. 2018 Jan 25;553(7689):515-520. View Abstract
Guggulsterone-releasing microspheres direct the differentiation of human induced pluripotent stem cells into neural phenotypes.
Agbay A, De La Vega L, Nixon G, Willerth SM.A Biomed Mater. 2018 Jan 25. doi: 10.1088/1748-605X/aaaa77 View Article
The Aspergillus fumigatus Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice
Nesbitt JR, Steves EY, Schonhofer CR, Cait A, Manku SS, Yeung JHF, Bennet AJ, McNagny KM, Choy JC, Hughes MR, Moore MM. Front Microbiol. 2018 Jan 18;8:2706. View Article
IL-6 expression is correlated with increased T-cell proliferation and survival in the arterial wall in giant cell arteritis
Manku S, Wong W, Luo Z, Seidman MA, Alabdurubalnabi Z, Rey K, Enns W, Avina-Zubieta JA, Shojania K, Choy JC. Cardiovasc Pathol. 2018 Mar – Apr;33:55-61. doi: 10.1016/j.carpath.2018.01.004. Epub 2018 Jan 9. View Article
Localized Tacrolimus Delivery Repairs the Damaged Central Nervous System
Willerth SM. EBioMedicine. 2017 Dec;26:4-5. View Article
Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell mediated TNFI signaling
Wang, W.,Fujii, H., et al., Zandstra, P.W. Science Translational Medicine.2017 Dec. 9:421 eaag3214
DOI: 10.1126/scitranslmed.aag3214 View Paper
FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors
Yoon, C., et al., Zandstra, P.W. Stem Cell Reports. 2018 Jan. 10:1-14. View Paper
Granzyme B in skin inflammation and disease
Turner CT, Lim D, Granville DJ.
Matrix Biol. 2017 Dec 14. pii: S0945-053X(17)30335-9. Review. View Abstract
Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture
Shen, Y., et al., Granville, D. Nature Scientific Reports. 2017 Nov. 7:15857, DOI:10.1038/s41598-017-16194-8. View Paper
3-D Bioprinting of Neural Tissue for Applications in Cell Therapy and Drug Screening
Thomas M, Willerth SM. Front Bioeng Biotechnol. 2017 Nov 17;5:69. View Paper
Modeling the behavior of human induced pluripotent stem cells seeded on melt electrospun scaffolds
Hall ME, Mohtaram NK, Willerth SM, Edwards R. J Biol Eng. 2017 Oct 23;11:38. View Article
Lentiviral Fluorescent Genetic Barcoding for Multiplex Fate Tracking of Leukemic Cells
Maetzig T, Ruschmann J, Sanchez Milde L, Lai CK, von Krosigk N, Humphries RK. Mol Ther Methods Clin Dev. 2017 Jun 1;6:54-65. View Paper
Myelin regulatory factor drives remyelination in multiple sclerosis
Duncan GJ, Plemel JR, Assinck P, Manesh SB, Muir FGW, Hirata R, Berson M, Liu J, Wegner M, Emery B, Moore GRW, Tetzlaff W.A Acta Neuropathol. 2017 Jun 19. doi: 10.1007/s00401-017-1741-7.A View Paper
Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury
Assinck P, Duncan GJ, Plemel JR, Lee MJ, Stratton JA, Manesh SB, Liu J, Ramer LM, Kang SH, Bergles DE, Biernaskie J, Tetzlaff W. J Neurosci. 2017 Sep 6;37(36):8635-8654.A View Paper
A stepwise model of Reaction-Diffusion and Positional-Information governs self-organized human peri-gastrulation-like patterning
Tewary M, Ostblom J, Prochazka L, Zulueta-Coarasa T, Shakiba N, Fernandez-Gonzalez R, Zandstra PW.A A Development. 2017 doi: 10.1242/dev.149658. [Epub ahead of print] View Paper
Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives
Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME, Hadjantonakis AK. Cell Rep. 2017 Aug 29;20(9):2116-2130. View Paper
Isolation, Culture, and Differentiation of Fibro/Adipogenic Progenitors (FAPs) from Skeletal Muscle
Judson RN, Low M, Eisner C, Rossi FM. Methods Mol Biol. 2017;1668:93-103.A View Paper
Repeatability of a Dislocation Spinal Cord Injury Model in a Rat – A High-Speed Biomechanical Analysis
Mattucci S, Liu J, Fijal P, Tetzlaff W, Oxland TR. J Biomech Eng. 2017 Oct 1;139(10). View Paper
Mechanically stable fibrin scaffolds induce neurite outgrowth and promote viability of neural aggregates derived from human induced pluripotent stem cells
Robinson, M., Douglas, S., andA Willerth, S.M.A A Scientific Reports. 2017. View Paper
Engineering neural tissue using stem cells
Dr. Willerth’s book came out on July 24th! Check it out here!
Differentiating heart failure with preserved and reduced ejection fraction through sex-specific transcriptomic and proteomic biomarker panels
Toma M, Mak G,A Chen V, Hollander Z, C, Lam K, Ng R, Tebbutt S, Wilson McManus J, Ignaszewski A, Anderson T, Dyck J, Howlett J,A Ezekowitz J, McManus BM, Oudit G. ESC Heart Failure. March 2017. View Paper
Biomarker development in COPD: moving from p-values to products to impact patient care
Sin D, Hollander Z, DeMarco M, Sadatsafavi M, McManus BM, Ng, Raymond. CHESTA February 2017; 151(2):455-467. View paper