Bruce McManus is Professor, Department of Pathology and Laboratory Medicine, at the University of British Columbia. He serves as the CEO of the Centre of Excellence for Prevention of Organ Failure (PROOF Centre), and as Co-Director of the Institute for Heart + Lung Health. Dr. McManus served as the inaugural Scientific Director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, from December 2000 until April 2006. Dr. McManus received BAPE and MD (WS Lindsay Gold Medalist) degrees at the University of Saskatchewan, an MSc in Applied Physiology from Pennsylvania State University, and PhD in Exercise Physiology and Biochemistry from the University of Toledo. He pursued post-doctoral fellowships in Environmental Physiology at the University of California – Santa Barbara and in Cardiovascular and Pulmonary Pathology at the National Heart, Lung, and Blood Institute in Bethesda, MD. Residency training at the Peter Bent Brigham Hospital – Harvard University in Internal Medicine and Pathology, was followed by specialization in Cardiovascular Pathology. After 11 years as a faculty member at the University of Nebraska Medical Centre, including John F. Fogarty Senior International Fellowship at the Max Planck Institute for Biochemistry, Martinsried, Dr. McManus joined the UBC Faculty of Medicine in July 1993. Dr. McManus’ basic and clinical investigative program addresses mechanisms, consequences, detection and prevention of injury and aberrant repair involved in inflammatory diseases of the heart (enterovirus infections) and blood vessels (allograft vasculopathy). He now focuses on molecular biosignature development and translation. Dr. McManus has co-authored ~400 peer-reviewed publications, as well as >50 chapters (h-index = 78, i10-index = 285). He has edited four books. He is co-holder of numerous patents.